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O  (h8!Research Progress on HIV Vaacines""(!    sUntil now, all the HIV vaccines trials are proven to be unsucsessful due to hyper mutation and immune escape of HIVt    HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. Z  gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM  $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PP^%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new HIV infections in men, 72% were in MSM, and of new infections in MSM, 46% were in whites, 35% were in blacks and 19% were in Hispanics.   , In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu. The mean infection rate among MSM is 5%(2% in US) 2010, MSM represented 10.8% of newly reported cases. In 2008, a large-scale cross-sectional survey of more than 18 000 MSM in 61 major cities of China found an HIV prevalence of 5.0% and a prevalence greater than 10% in several southwest cities jnZZnZZ    -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  MThe first confirmed MSM case, a man in Beijing, in mainland China was in 1989. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community Nr3M  : These results highlight that student MSM, despite their high level of education and the previous perception that they are a low-risk group by researchers, have actually become a high-risk population for HIV infection in China.   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. FPqp 1#Health Intervention to MSM in China($#((#  In view of tradition and current status, at least four factors play roles in spread and control of HIV among MSM in China. (1) a mainstream belief on relation between fertility and sex that is inherited from belief as early as the twentieth century; (2) Ideologized and stereotyped same-gender sex and its residual effects, beginning politically and culturally from 1900-1970; (3) Effects on understanding of same-gender sex of China s Opening and Reform Policies beginning from 1980 and the globalization trend in the world; (4) Development of China s society and their response to AIDS. NPNM  5 There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. Z  6Prevention of HIV among MSM  Pexpand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies, condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) )P)(  7  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! 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O 2=""M""   H  0޽h ? 3___PPT10i.H+D=' = @B +" 0     (  &  J?ckeb_/web_ 4m $Epidemiology of HIV in United States% % 6     D  Dj?ckeb_/web_ 6Z<___PPT10Z___PPT9<4  In 2009, people living with HIV or AIDS in the world: 33.3 million. In US, by the end of 2010, 1,200,000 adults and children were estimated to be living with HIV. Among them, 17,774 died of HIV-related causes in 2009.  5"" &" c  g G c  g & c  "  " <                   G    &     <A 1?"6@ NNN?N y  <ě 1?"6@ NNN?NY M` eUNAIDS Global AIDS Response Progress Reporting 2012 UNITED STATES OF AMERICA Country Progress Report *f 2eaae  | `> \4 S .0000S 2"Zp  A??Zprevalence_mapPicture 3C:\Users\Lijun Gu\Desktop\prevalence_map.png`u>/  \A???Picture 4 /> \4  \A???Picture 5`>`uH  0޽h ? 3___PPT10i.B+D=' = @B +"0 L~(  L L J\&5?ckeb_/web_ 4m Epidemiology of HIV in China  6      F L D-5?ckeb_/web_ 6 T In China, by the end of 2011, 780,000 adults and children were estimated to be living with HIV. Among them, 28,000 died of HIV-related causes in 2011. By August of 2010, cumulative number of PLHIV receiving ART was 100,000 in China. """&G"&g"& " "           G        7     L A?fԔ?:China HIVPicture 7E:\IM\Paper\f[O\China HIV.jpg!F H L 0޽h ? 3___PPT10i.B+D=' = @B + 0 P2E(  X . C 0A 51dv4iDxreLf   jpO??Rectangle 127"@J q  &    r / S WFY   r 1 S d\p K   - s *Y?'g% > H ! 0޽h ? 3___PPT10i.F0&M+D=' = @B +"C 0 JBp8(  (  ft1??Text Box 57 HIV Treatment- HARRT, 2$&$   r 7 S  ;  H 5 0޽h ? 3___PPT10i. +D=' = @B +"=0 D<0 (    J?ckeb_/web_ 2  w HIV Cure:         F ?ckeb_/web_ 12i - After 2012, HIV cure gradually became a hotspot in HIV reseach. It commonly includes novel drugs, gene therapy, and bone marrow transplantation (BMT) > Z@&&   H   0޽h ? 3___PPT10i.E0V%p+D=' = @B +" 0 G v(     T# ?Rectangle 2"@ g L ^  e  r C S $  `}   r D S  '     R F C *A untitled@ H @ 0޽h ? 3___PPT10i.H+D=' = @B +"E 0 LD $(  $ $ Xϰ1?Rectangle 259"@T HIV Epidemic among MSM in US $    $ <A 1?"6@ NNN?N~4 r $ S e `}  5 r $ S o    r  $ S ܤ, Z  f  $ Bh 1?"6@ NNN?N-Q M f Centers for Disease Control and Prevention. HIV prevalence estimates: United States, 2006. MMWR 2008;g(2gag H $ 0޽h ? 3___PPT10i.})+D=' = @B +" 0  X (  > S X1?Rectangle 259"@8 $HIV Epidemic among MSM in US (cont.)2% &$g$$   r W S Lo:z' o  X <4o 1?"6@ NNN?Nw% B AJoseph A. Catania et al. American Journal of Public Health, 2001 bA8nFP 2c(cgA  H  0޽h ? 3___PPT10i.n`iR+D=' = @B + 0 JB@(  r  S  `  (  s L0e0e1?Rectangle 2593"0e@ `}    H  0޽h ? 380___PPT10.=`^Q 0 p(  r  S V ` V   S ~m0e0e?#" 0e }   H  0޽h ? 380___PPT10.= 6 0 ]U(    S   `   "p`Pp%  X u1?Rectangle 259"@w|  !HIV Epidemic among MSM in China " "&$!   H  0޽h ? 380___PPT10.=#K  0  (  r  S ,( `}  o n   :0e0eA     @  1 8c8c     ?A)BCD|E||# "0e@       @ABC DEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN 5%  N 5%  N    5%    !"?N@ABC DEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab H  0޽h ? 380___PPT10.=0N$ 0  $(   r   S  - `}  - r   S - ` - H   0޽h ? 380___PPT10.=> 0 \(  \r \ S b `}  b  \ C xHo0e0e?#" 0e ` o H \ 0޽h ? 380___PPT10.j>dD$ 0 X$(  Xr X S Њ `}   r X S p' `  H X 0޽h ? 380___PPT10.i>Pϑ$ 0 $(  r  S 5(^B.  ( r  S 0  ` ( H  0޽h ? 380___PPT10.:>P/$ 0 ($(  (r ( S S `}   r ( S V `  H ( 0޽h ? 380___PPT10.?> .$ 0  ,$(  ,r , S $D `}   r , S  `  H , 0޽h ? 380___PPT10.B>,'  0 > 6 0 0 (  0r 0 S  `}   n 0  :0e0eA     @  1 8c8c     ?A)BCD|E||# "0e@       @ABC DEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN 5%  N 5%  N    5%    !"?N@ABC DEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab2   0 <A 1?"6@ NNN?N2 0 B 1?"6@ NNN?N`C B  0 BD1?"0@NNN?N  2  0 < 31?"6@ NNN?Ne H 0 0޽h ? 3___PPT10i.S>pv+D=' = @B +  0 H(  H H H?M?Rectangle 2"@wP j Conclusion  x $    H H\SM?Rectangle 3pcD<4___PPT9  HIV has become a chronic infectious disease due to HARRT adoption. However, HIV vaccines are not developed sucssesfully. MSM community is still the at-risk population in transmitting HIV. HIV epidemic among MSM between US and China not only share a variety of similarities, but also differnces due to cultural difference and political system. 3. in terms of HIV prevention among MSM community, corresponding measures should be adopted for prophylysis .BZ! r  ""y  B     n   H Tdb5 1?"6@ NNN?N  +   H Tb5 1?"6@ NNN?N  +   H T`o7 1?"6@ NNN?N m  +  H H 0޽h ? 3___PPT10i.K\!+D=' = @B +" 0 `=(  `r ` S 䅡 `}   r ` S  `   ` C AJJmh370_china_prayers_11032014-936x620International school students light candles to pray for passengers aboard Malaysia Airlines flight MH370, in Zhuji, Zhejiang province, March 10, 2014.  Reuters pic 5 ` <ǡ 1?"6@ NNN?N Tw - 153 Chinese and 38 Malaysians disappeared!!!. 2.c -  H ` 0޽h ? 3___PPT10i.m>`+D=' = @B +h0 .&P(  P P  reeL?Rectangle 27[    P  ee5%L?Rectangle 3 u   lRapid high throughput screening of drug resistance in HIV-HBV co-infected patients by PCR-SSOP Luminex assay4_    H P 0-f ? 3380___PPT10.2m 0 o g T (  T T  eeL?*0000 0000 00000000 17[   U  T  TUee5%L?000 00000000 2 u  U ` The Joint United Nations Programme on HIV/AIDS (UNAIDS) and World Health Organization (WHO) estimated that 2.6 million new HIV infections and 1.8 million AIDS death occurred in 2009, and almost 33.3 million adults and children worldwide are currently living with HIV or AIDS, the great majority of them in the developing world. Asia, home to 60% of the world s population, is second only to sub-Saharan Africa in terms of the number of people living with HIV. In 2009, 4.9 million people in Asia were living with HIV, including 360000 who became newly infected last year, and 300000 AIDS related deaths occurred. In China, by the end of 2009, 740,000 (range 560,000-920,000) adults and children were estimated to be living with HIV, with 48,000 (range 41,000-55,000) new infections taking place in this year. Among them, 105,000 (range 97,000 -112,000) were estimated to be AIDS cases and 26,000 (range 22,000-30,000) to have died of HIV-related causes in 2009. Free ARV (antiretroviral) treatment program began in 2003, by August of 2010, cumulative number of adult PLHIV (people living with HIV) received ART (antiretroviral therapy) was 95,631and PLHIV aged less than 15 received ART was 2,009. 4      - T pXUee?"0000juS00000000 3c F  |* A   H T 0-f ? 3380___PPT10.,`0 @Xp(  X X  eeL?*0000 0000 00000000 17[   U7 X  cUee5%L?000 00000000 2 u  U 5The World Health Organization (WHO) estimated that About 2 billion people worldwide have been infected with the hepatitis B virus and about 350 million live with chronic infection. An estimated 600 000 persons die each year due to the acute or chronic consequences of hepatitis B. 10% of HIV infected patients are chronically infected with HBV. In China, HBV infection is highly endemic. The seroepidemiological survey on HBV infection conducted in 2006 showed that HBsAg carrier rate was 7.18% in the overall population. Accordingly there were an estimated 93 million HBV carriers, and among them 30 million were patients with chronic hepatitis B. &nN  7     - X pthUee?"0000juS00000000 3c F  |* A   H X 0-f ? 3380___PPT10.Q7 0   `\(  \ \  eeL?*0000 0000 00000000 17[   Un \  \Uee5%L?000 00000000 2 u  U8___PPT10N___PPT90( nA combination ART regimen generally consists of two NRTIs and one active drug from one of the following classes: NNRTI, PI (generally boosted with RTV), INSTI, or a CCR5 antagonist in industrialized countries. The use of standardized and affordable first-line combinations of antiretroviral drugs through a public health approach, including two NRTIs and one NNRTI, has been crucial to allow the scale up of ART in low- and middle- income countries. However, the cost of laboratory monitoring of patients has meant that viral load measurements and DR tests are not generally recommended by WHO. Drug resistance reached up to over 30% in provinces where free ARV treatment program began in 2003, for instance, 30.3% in Henan province, 26.6% in Anhui province and 19.2% in Hubei province. It is estimated that 8000 -10,000 patients would be requiring second-line drugs in China. @o"a   '      D  !  R    *    - \ pUee?"0000juS00000000 3c F  |* A   H \ 0-f ? 3380___PPT10.W0 `(  `# ` fUee?Rectangle 7c F  |* A    `  r0e0eL?Rectangle 27[   U `  Uee5%L?Rectangle 3 u  U 0After 1996, harrt is used commaonly in the world110   H ` 0-f ? 3380___PPT10.H/]g0 }d(  d d  eeL?(0000 0000 0000000 17[   U d  7Uee5%L?000 0000000 2 u  U  The main mutations conferring resistance to 3TC both in vivo and in vitro correspond to a methionine (M) to valine (V) or isoleucine (I) change at amino acid 204 within the YMDD catalytic domain of HBV RT. The mutation RT M204V is frequently associated in vivo with compensatory mutations, RT V173L and/or RT L180M, that partially restore the replicative capacity of the YVDD-mutant strains. The emergence of these mutations compromises the clinical efficacy of this drug and therefore limits its use. Treatment with 3TC results in a rapid decrease of the serum viral load and is associated most of the time with an improvement of the patient's condition. Unfortunately, this improvement is often transient as viral resistance develops rapidly, reaching more than 70% of patients after 5 years. Based on the established PCR-SSOP-Luminex assay in HIV-1 drug resistance, we used the system to determine the presence or absence of the RT M204V/I, RT L180M and RT V173L, and RT mutations in plasmas from HIV-HBV co-infected patients and from HBV mono-infected patients by the PCR-SSOP-Luminex assay. 0000o0;Nj08hx0000dRk0[W00'`00_00W0_0000000/⎙Qu }Wk0 Ypu0:yW0~0Y0000000lBvn0g'Yn0OULpo0000000n0YMDD 0000L0YIDD ~0_0o0YVDD k0 YpuY00h0'`h0j00~0Y00~0_00rt204Vk04OY00 Ypuh0W0f00180juvn00000L000000k0ncU000 Ypu0Ss0173juvn0000L00000k0ncU000 YpuL0w00f0D0~0Y00 000Vg0n0ba'`BWpn0lBvsr0naW0f0000000 YpuWQsn0ŏ, ckxj0:eL0_g00b0o09jzW0_0HIVdR'`ign0PCR-SSOP-LuminexRg00000Oc0f00HBVn030@bn0 Ypu0@wvW0f0iW0~0W0_00Z        W  D     "     `          o    ! &       &          + d nVee? 0000juS0000000 3c F  |* A   H d 0-f ? 3380___PPT10.j>w0 h(  h h  eeL?(0000 0000 0000000 17[   VR h  ,Uee5%L?000 0000000 2 u  V RZ  + h n9Vee? 0000juS0000000 3c F  |* A   H h 0-f ? 3380___PPT10.<~K0  (     eeL?(0000 0000 0000000 17[   of   !oee5%L?000 0000000 2 u  o fIn conclusion, we established a detection system for K103N and M184V resistance mutation in different HIV-1 subtypes infected patients with PCR-SSOP-Luminex assay. This novel method is rapid, simple, and high throughput. With the development of suitable primers and oligoprobes, this assay may be an appropriate technique for the surveillance of transmitted HIV drug resistance, clinical practice and public health research in low- and middle-income countries. h   f     +  nTWoee? 0000juS0000000 3c F  |* A   H  0-f ? 3380___PPT10.PauF 0 j b P (  P P  eeL?*0000 0000 00000000 17[   5  P  p8ee5%L?000 00000000 2 u  5 ` The Joint United Nations Programme on HIV/AIDS (UNAIDS) and World Health Organization (WHO) estimated that 2.6 million new HIV infections and 1.8 million AIDS death occurred in 2009, and almost 33.3 million adults and children worldwide are currently living with HIV or AIDS, the great majority of them in the developing world. Asia, home to 60% of the world s population, is second only to sub-Saharan Africa in terms of the number of people living with HIV. In 2009, 4.9 million people in Asia were living with HIV, including 360000 who became newly infected last year, and 300000 AIDS related deaths occurred. In China, by the end of 2009, 740,000 (range 560,000-920,000) adults and children were estimated to be living with HIV, with 48,000 (range 41,000-55,000) new infections taking place in this year. Among them, 105,000 (range 97,000 -112,000) were estimated to be AIDS cases and 26,000 (range 22,000-30,000) to have died of HIV-related causes in 2009. Free ARV (antiretroviral) treatment program began in 2003, by August of 2010, cumulative number of adult PLHIV (people living with HIV) received ART (antiretroviral therapy) was 95,631and PLHIV aged less than 15 received ART was 2,009. 4       P pD.5ee?"0000juS00000000 3c F |* A   H P 0-f ? 3380___PPT10.,r"@~6&"0<14H(G / 0DTimes New RomanLLԖׯ0ԖD-3 00000 RomanLLԖׯ0Ԗ" DOh+'0 hp   饤 1 ұۼStream ľ891Microsoft Office PowerPoint@0jh$@> U@ n> Ghg  ,V'&" WMFCI <8, :8I $$R$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YL$b$j7$E<ƛT W 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3^ʚ;2ʚ;<4ddddS0g4EdEdׯ0ppp@ <4!d!dvS0L<4BdBdvS0L )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp~___PPT9`X@?  O  (h8!Research Progress on HIV Vaacines""(!    sUntil now, all the HIV vaccines trials are proven to be unsucsessful due to hyper mutation and immune escape of HIVt    HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. Z  gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM  $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PP^%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. 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" # $ % & ' m D F G H I J K L M N O P Q R S T U V W X Y Z [ \ ] ^ _ ` a b c d e f g h  k l n o p q r s t u v w x y z { | }  Root EntrydO) n>j PicturesFCurrent User8SummaryInformation( PowerPoint Document( I]DocumentSummaryInformation8LArial00 RomanLLԖׯ0Ԗ"0DGaramond RomanLLԖׯ0Ԗ@DWingdingsRomanLLԖׯ0ԖPD-3 0fggsRomanLLԖׯ0Ԗ`DHGPfgBgsRomanLLԖׯ0Ԗe(.2 @n?" dd@   @@``  `Y" 39H KE8';*, -     /Y84789 :=ABC JKMNOR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $$R$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YL$b$j7$E<ƛT W 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3^ʚ;2ʚ;<4ddddS0g4EdEdׯ0ppp@ <4!d!dvS0L<4BdBdvS0L )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp~___PPT9`X@?  O  (h8!Research Progress on HIV Vaacines""(!    sUntil now, all the HIV vaccines trials are proven to be unsucsessful due to hyper mutation and immune escape of HIVt    HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. Z  gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM  $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PP^%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new HIV infections in men, 72% were in MSM, and of new infections in MSM, 46% were in whites, 35% were in blacks and 19% were in Hispanics.   , In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu. The mean infection rate among MSM is 5%(2% in US) 2010, MSM represented 10.8% of newly reported cases. In 2008, a large-scale cross-sectional survey of more than 18 000 MSM in 61 major cities of China found an HIV prevalence of 5.0% and a prevalence greater than 10% in several southwest cities jnZZnZZ    -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  MThe first confirmed MSM case, a man in Beijing, in mainland China was in 1989. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community Nr3M  : These results highlight that student MSM, despite their high level of education and the previous perception that they are a low-risk group by researchers, have actually become a high-risk population for HIV infection in China.   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. FPqp 1#Health Intervention to MSM in China($#((#  In view of tradition and current status, at least four factors play roles in spread and control of HIV among MSM in China. (1) a mainstream belief on relation between fertility and sex that is inherited from belief as early as the twentieth century; (2) Ideologized and stereotyped same-gender sex and its residual effects, beginning politically and culturally from 1900-1970; (3) Effects on understanding of same-gender sex of China s Opening and Reform Policies beginning from 1980 and the globalization trend in the world; (4) Development of China s society and their response to AIDS. NPNM  5 There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. Z  6Prevention of HIV among MSM  Pexpand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies, condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) )P)(  7  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr{hz@<14H(G / 0DTimes New RomanLL ՜.+,0   $,4 < Ļʾ4|ѧҽѧоȶҽо󥿩`Ⱦ֢ҰI] ' #Times New Romanͣ ХåArial Garamond Wingdings ͣ HGPBStream õƬ 1 õƬ 2 õƬ 3!Research Progress on HIV Vaccine õƬ 5 õƬ 6Berlin Patient õƬ 8 õƬ 9%HIV Epidemic among MSM in US (cont.)%HIV Epidemic among MSM in US (cont.) õƬ 12 õƬ 13 õƬ 14'HIV Epidemic among MSM in China(cont.)'HIV Epidemic among MSM in China(cont.)'HIV Epidemic among MSM in China(cont.)'HIV Epidemic among MSM in China(cont.)'HIV Epidemic among MSM in China(cont.)'HIV Epidemic among MSM in China(cont.)Prophylaxis for HIV among MSMProphylaxis for HIV among MSMProphylaxis for HIV among MSM$Looking at What does Scient _%]ľ薗g(gΘists Say õƬ 25Acknowledgement;Pray for passengers aboard Malaysia Airlines flight MH370  õʾĸģ õƬs alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new HIV infections in men, 72% were in MSM, and of new infections in MSM, 46% were in whites, 35% were in blacks and 19% were in Hispanics.   , In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu. The mean infection rate among MSM is 5%(2% in US) 2010, MSM represented 10.8% of newly reported cases. In 2008, a large-scale cross-sectional survey of more than 18 000 MSM in 61 major cities of China found an HIV prevalence of 5.0% and a prevalence greater than 10% in several southwest cities jnZZnZZ    -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  MThe first confirmed MSM case, a man in Beijing, in mainland China was in 1989. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community Nr3M  : These results highlight that student MSM, despite their high level of education and the previous perception that they are a low-risk group by researchers, have actually become a high-risk population for HIV infection in China.   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. FPqp 1#Health Intervention to MSM in China($#((#  In view of tradition and current status, at least four factors play roles in spread and control of HIV among MSM in China. (1) a mainstream belief on relation between fertility and sex that is inherited from belief as early as the twentieth century; (2) Ideologized and stereotyped same-gender sex and its residual effects, beginning politically and culturally from 1900-1970; (3) Effects on understanding of same-gender sex of China s Opening and Reform Policies beginning from 1980 and the globalization trend in the world; (4) Development of China s society and their response to AIDS. NPNM  5 There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. Z  6Prevention of HIV among MSM  Pexpand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies, condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) )P)(  7  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels (  0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrthP <14H(G / 0DTimes New RomanLLԖׯ0ԖD-3 00000 RomanLLԖׯ0Ԗ" DArial00 RomanLLԖׯ0Ԗ"0DGaramond RomanLLԖׯ0Ԗ@DWingdingsRomanLLԖׯ0ԖPD-3 0fggsRomanLLԖׯ0Ԗ`DHGPfgBgsRomanLLԖׯ0Ԗe(.2 @n?" dd@   @@``  `Y" 39H KE8';*, -     /Y84789 :=ABC JKMNOR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $$R$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YL$b$j7$E<ƛT W 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3^ʚ;2ʚ;<4ddddS0g4EdEdׯ0ppp@ <4!d!dvS0L<4BdBdvS0L )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp~___PPT9`X@?  O  (h8!Research Progress on HIV Vaacines""(!    sUntil now, all the HIV vaccines trials are proven to be unsucsessful due to hyper mutation and immune escape of HIVt    HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. Z  gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM  $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PP^%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new HIV infections in men, 72% were in MSM, and of new infections in MSM, 46% were in whites, 35% were in blacks and 19% were in Hispanics.   , In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu. The mean infection rate among MSM is 5%(2% in US) 2010, MSM represented 10.8% of newly reported cases. In 2008, a large-scale cross-sectional survey of more than 18 000 MSM in 61 major cities of China found an HIV prevalence of 5.0% and a prevalence greater than 10% in several southwest cities jnZZnZZ    -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  MThe first confirmed MSM case, a man in Beijing, in mainland China was in 1989. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community Nr3M  : These results highlight that student MSM, despite their high level of education and the previous perception that they are a low-risk group by researchers, have actually become a high-risk population for HIV infection in China.   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. FPqp 1#Health Intervention to MSM in China($#((#  In view of tradition and current status, at least four factors play roles in spread and control of HIV among MSM in China. (1) a mainstream belief on relation between fertility and sex that is inherited from belief as early as the twentieth century; (2) Ideologized and stereotyped same-gender sex and its residual effects, beginning politically and culturally from 1900-1970; (3) Effects on understanding of same-gender sex of China s Opening and Reform Policies beginning from 1980 and the globalization trend in the world; (4) Development of China s society and their response to AIDS. NPNM  5 There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. Z  6Prevention of HIV among MSM  Pexpand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies, condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) )P)(  7  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr h  T<14H(G / 0DTimes New RomanLLԖׯ0ԖD-3 00000 RomanLLԖׯ0Ԗ" DArial00 RomanLLԖׯ0Ԗ"0DGaramond RomanLLԖׯ0Ԗ@DWingdingsRomanLLԖׯ0ԖPD-3 0fggsRomanLLԖׯ0Ԗ`DHGPfgBgsRomanLLԖׯ0Ԗe(.2 @n?" dd@   @@``  `Y" 39H KE8';*, -     /Y84789 :=ABC JKMNOR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $$R$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YL$b$j7$E<ƛT W 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3^ʚ;2ʚ;<4ddddS0g4EdEdׯ0ppp@ <4!d!dvS0L<4BdBdvS0L )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp~___PPT9`X@?  O  (h8!Research Progress on HIV Vaacines""(!    sUntil now, all the HIV vaccines trials are proven to be unsucsessful due to hyper mutation and immune escape of HIVt    HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. Z  gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM  $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PP^%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new HIV infections in men, 72% were in MSM, and of new infections in MSM, 46% were in whites, 35% were in blacks and 19% were in Hispanics.   , In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu. The mean infection rate among MSM is 5%(2% in US) 2010, MSM represented 10.8% of newly reported cases. In 2008, a large-scale cross-sectional survey of more than 18 000 MSM in 61 major cities of China found an HIV prevalence of 5.0% and a prevalence greater than 10% in several southwest cities jnZZnZZ    -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  MThe first confirmed MSM case, a man in Beijing, in mainland China was in 1989. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community Nr3M  : These results highlight that student MSM, despite their high level of education and the previous perception that they are a low-risk group by researchers, have actually become a high-risk population for HIV infection in China.   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. FPqp 1#Health Intervention to MSM in China($#((#  In view of tradition and current status, at least four factors play roles in spread and control of HIV among MSM in China. (1) a mainstream belief on relation between fertility and sex that is inherited from belief as early as the twentieth century; (2) Ideologized and stereotyped same-gender sex and its residual effects, beginning politically and culturally from 1900-1970; (3) Effects on understanding of same-gender sex of China s Opening and Reform Policies beginning from 1980 and the globalization trend in the world; (4) Development of China s society and their response to AIDS. NPNM  5 There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. Z  6Prevention of HIV among MSM  Pexpand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies, condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) )P)(  7  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrTTh0T<14H(G / 0DTimes New RomanLLԖׯ0ԖD-3 00000 RomanLLԖׯ0Ԗ" DArial00 RomanLLԖׯ0Ԗ"0DGaramond RomanLLԖׯ0Ԗ@DWingdingsRomanLLԖׯ0ԖPD-3 0fggsRomanLLԖׯ0Ԗ`DHGPfgBgsRomanLLԖׯ0Ԗe(.2 @n?" dd@   @@``  `Y" 39H KE8';*, -     /Y84789 :=ABC JKMNOR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $$R$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YL$b$j7$E<ƛT W 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3^ʚ;2ʚ;<4ddddS0g4EdEdׯ0ppp@ <4!d!dvS0L<4BdBdvS0L )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp~___PPT9`X@?  O  (h8!Research Progress on HIV Vaacines""(!    sUntil now, all the HIV vaccines trials are proven to be unsucsessful due to hyper mutation and immune escape of HIVt    HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. Z  gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM  $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PP^%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new HIV infections in men, 72% were in MSM, and of new infections in MSM, 46% were in whites, 35% were in blacks and 19% were in Hispanics.   , In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu. The mean infection rate among MSM is 5%(2% in US) 2010, MSM represented 10.8% of newly reported cases. In 2008, a large-scale cross-sectional survey of more than 18 000 MSM in 61 major cities of China found an HIV prevalence of 5.0% and a prevalence greater than 10% in several southwest cities jnZZnZZ    -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  MThe first confirmed MSM case, a man in Beijing, in mainland China was in 1989. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community Nr3M  : These results highlight that student MSM, despite their high level of education and the previous perception that they are a low-risk group by researchers, have actually become a high-risk population for HIV infection in China.   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. FPqp 1#Health Intervention to MSM in China($#((#  In view of tradition and current status, at least four factors play roles in spread and control of HIV among MSM in China. (1) a mainstream belief on relation between fertility and sex that is inherited from belief as early as the twentieth century; (2) Ideologized and stereotyped same-gender sex and its residual effects, beginning politically and culturally from 1900-1970; (3) Effects on understanding of same-gender sex of China s Opening and Reform Policies beginning from 1980 and the globalization trend in the world; (4) Development of China s society and their response to AIDS. NPNM  5 There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. Z  6Prevention of HIV among MSM  Pexpand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies, condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) )P)(  7  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrĜh<1K(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@``  h[# 39H KE8';*, -     /Y84789 :=ABC JKMNOPR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $$R$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YL$b$j7$E<ƛT W 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3Vʚ;2ʚ;<4ddddS0g4EdEdəׯ00ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ ppv___PPT9XP8?  O  y,h8!Research Progress on HIV Vaacines""(!    sUntil now, all the HIV vaccines trials are proven to be unsucsessful due to hyper mutation and immune escape of HIVt    HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. Z  gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM  $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PP^%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV inc      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{}~idence among black MSM was 8.0 times higher than among white MSM. Of new HIV infections in men, 72% were in MSM, and of new infections in MSM, 46% were in whites, 35% were in blacks and 19% were in Hispanics.   , In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu. The mean infection rate among MSM is 5%(2% in US) 2010, MSM represented 10.8% of newly reported cases. In 2008, a large-scale cross-sectional survey of more than 18 000 MSM in 61 major cities of China found an HIV prevalence of 5.0% and a prevalence greater than 10% in several southwest cities jnZZnZZ    -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  MThe first confirmed MSM case, a man in Beijing, in mainland China was in 1989. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community Nr3M  : These results highlight that student MSM, despite their high level of education and the previous perception that they are a low-risk group by researchers, have actually become a high-risk population for HIV infection in China.   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. FPqp 1#Health Intervention to MSM in China($#((#  In view of tradition and current status, at least four factors play roles in spread and control of HIV among MSM in China. (1) a mainstream belief on relation between fertility and sex that is inherited from belief as early as the twentieth century; (2) Ideologized and stereotyped same-gender sex and its residual effects, beginning politically and culturally from 1900-1970; (3) Effects on understanding of same-gender sex of China s Opening and Reform Policies beginning from 1980 and the globalization trend in the world; (4) Development of China s society and their response to AIDS. NPNM  5 There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. Z  6Prevention of HIV among MSM  Pexpand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies, condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) )P)(  7  =Acknowledgement School of Publich Health, Drexel University and Upenn: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff (   China CDC: Yiming Shao, M.D, Ph.D Guodong Mi, Ph.D, MPH Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China (  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPK 0 d(  dr d S x `}   r d S I    r d S xJp `  H d 0޽h ? 380___PPT10.p> dr4=91h3=1K(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@``  h[# 39H KE8';*, -     /Y84789 :=ABC JKMNOPR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $$R$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YL$b$j7$E<ƛT W 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3Vʚ;2ʚ;<4ddddS0g4EdEdəׯ00ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ ppv___PPT9XP8?  O  y,h8!Research Progress on HIV Vaacines""(!    sUntil now, all the HIV vaccines trials are proven to be unsucsessful due to hyper mutation and immune escape of HIVt    HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. Z  gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM  $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PP^%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new HIV infections in men, 72% were in MSM, and of new infections in MSM, 46% were in whites, 35% were in blacks and 19% were in Hispanics.   , In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu. The mean infection rate among MSM is 5%(2% in US) 2010, MSM represented 10.8% of newly reported cases. In 2008, a large-scale cross-sectional survey of more than 18 000 MSM in 61 major cities of China found an HIV prevalence of 5.0% and a prevalence greater than 10% in several southwest cities jnZZnZZ    -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  MThe first confirmed MSM case, a man in Beijing, in mainland China was in 1989. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community Nr3M  : These results highlight that student MSM, despite their high level of education and the previous perception that they are a low-risk group by researchers, have actually become a high-risk population for HIV infection in China.   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. FPqp 1#Health Intervention to MSM in China($#((#  In view of tradition and current status, at least four factors play roles in spread and control of HIV among MSM in China. (1) a mainstream belief on relation between fertility and sex that is inherited from belief as early as the twentieth century; (2) Ideologized and stereotyped same-gender sex and its residual effects, beginning politically and culturally from 1900-1970; (3) Effects on understanding of same-gender sex of China s Opening and Reform Policies beginning from 1980 and the globalization trend in the world; (4) Development of China s society and their response to AIDS. NPNM  5 There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. Z  6Prevention of HIV among MSM  Pexpand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies, condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) )P)(  7  =Acknowledgement School of Publich Health, Drexel University and Upenn: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff (   China CDC: Yiming Shao, M.D, Ph.D Guodong Mi, Ph.D, MPH Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China (  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr4h3 =1K(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@``  h[# 39H KE8';*, -     /Y84789 :=ABC JKMNOPR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $$R$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YL$b$j7$E<ƛT W 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3Vʚ;2ʚ;<4ddddS0g4EdEdəׯ00ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ ppv___PPT9XP8?  O  y,h8!Research Progress on HIV Vaacines""(!    sUntil now, all the HIV vaccines trials are proven to be unsucsessful due to hyper mutation and immune escape of HIVt    HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. Z  gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM  $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PP^%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new HIV infections in men, 72% were in MSM, and of new infections in MSM, 46% were in whites, 35% were in blacks and 19% were in Hispanics.   , In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu. The mean infection rate among MSM is 5%(2% in US) 2010, MSM represented 10.8% of newly reported cases. In 2008, a large-scale cross-sectional survey of more than 18 000 MSM in 61 major cities of China found an HIV prevalence of 5.0% and a prevalence greater than 10% in several southwest cities jnZZnZZ    -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  MThe first confirmed MSM case, a man in Beijing, in mainland China was in 1989. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community Nr3M  : These results highlight that student MSM, despite their high level of education and the previous perception that they are a low-risk group by researchers, have actually become a high-risk population for HIV infection in China.   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. FPqp 1#Health Intervention to MSM in China($#((#  In view of tradition and current status, at least four factors play roles in spread and control of HIV among MSM in China. (1) a mainstream belief on relation between fertility and sex that is inherited from belief as early as the twentieth century; (2) Ideologized and stereotyped same-gender sex and its residual effects, beginning politically and culturally from 1900-1970; (3) Effects on understanding of same-gender sex of China s Opening and Reform Policies beginning from 1980 and the globalization trend in the world; (4) Development of China s society and their response to AIDS. NPNM  5 There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. Z  6Prevention of HIV among MSM  Pexpand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies, condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) )P)(  7  =Acknowledgement School of Publich Health, Drexel University and Upenn: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff (   China CDC: Yiming Shao, M.D, Ph.D Guodong Mi, Ph.D, MPH Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China (  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrTh0Y=1K(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@``  h[# 39H KE8';*, -     /Y84789 :=ABC JKMNOPR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $$R$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YL$b$j7$E<ƛT W 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3Vʚ;2ʚ;<4ddddS0g4EdEdəׯ00ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ ppv___PPT9XP8?  O  y,h8!Research Progress on HIV Vaacines""(!    sUntil now, all the HIV vaccines trials are proven to be unsucsessful due to hyper mutation and immune escape of HIVt    HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. Z  gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM  $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PP^%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new HIV infections in men, 72% were in MSM, and of new infections in MSM, 46% were in whites, 35% were in blacks and 19% were in Hispanics.   , In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu. The mean infection rate among MSM is 5%(2% in US) 2010, MSM represented 10.8% of newly reported cases. In 2008, a large-scale cross-sectional survey of more than 18 000 MSM in 61 major cities of China found an HIV prevalence of 5.0% and a prevalence greater than 10% in several southwest cities jnZZnZZ    -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  MThe first confirmed MSM case, a man in Beijing, in mainland China was in 1989. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community Nr3M  : These results highlight that student MSM, despite their high level of education and the previous perception that they are a low-risk group by researchers, have actually become a high-risk population for HIV infection in China.   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. FPqp 1#Health Intervention to MSM in China($#((#  In view of tradition and current status, at least four factors play roles in spread and control of HIV among MSM in China. (1) a mainstream belief on relation between fertility and sex that is inherited from belief as early as the twentieth century; (2) Ideologized and stereotyped same-gender sex and its residual effects, beginning politically and culturally from 1900-1970; (3) Effects on understanding of same-gender sex of China s Opening and Reform Policies beginning from 1980 and the globalization trend in the world; (4) Development of China s society and their response to AIDS. NPNM  5 There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. Z  6Prevention of HIV among MSM  Pexpand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies, condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) )P)(  7  =Acknowledgement School of Publich Health, Drexel University and Upenn: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff (   China CDC: Yiming Shao, M.D, Ph.D Guodong Mi, Ph.D, MPH Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China (  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrhi=1K(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@``  h[# 39H KE8';*, -     /Y84789 :=ABC JKMNOPR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $$R$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YL$b$j7$E<ƛT W 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3Vʚ;2ʚ;<4ddddS0g4EdEdəׯ00ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ ppv___PPT9XP8?  O  y,h8!Research Progress on HIV Vaacines""(!    sUntil now, all the HIV vaccines trials are proven to be unsucsessful due to hyper mutation and immune escape of HIVt    HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. Z  gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM  $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PP^%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new HIV infections in men, 72% were in MSM, and of new infections in MSM, 46% were in whites, 35% were in blacks and 19% were in Hispanics.   , In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu. The mean infection rate among MSM is 5%(2% in US) 2010, MSM represented 10.8% of newly reported cases. In 2008, a large-scale cross-sectional survey of more than 18 000 MSM in 61 major cities of China found an HIV prevalence of 5.0% and a prevalence greater than 10% in several southwest cities jnZZnZZ    -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  MThe first confirmed MSM case, a man in Beijing, in mainland China was in 1989. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community Nr3M  : These results highlight that student MSM, despite their high level of education and the previous perception that they are a low-risk group by researchers, have actually become a high-risk population for HIV infection in China.   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. FPqp 1#Health Intervention to MSM in China($#((#  In view of tradition and current status, at least four factors play roles in spread and control of HIV among MSM in China. (1) a mainstream belief on relation between fertility and sex that is inherited from belief as early as the twentieth century; (2) Ideologized and stereotyped same-gender sex and its residual effects, beginning politically and culturally from 1900-1970; (3) Effects on understanding of same-gender sex of China s Opening and Reform Policies beginning from 1980 and the globalization trend in the world; (4) Development of China s society and their response to AIDS. NPNM  5 There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. Z  6Prevention of HIV among MSM  Pexpand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies, condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) )P)(  7  =Acknowledgement School of Publich Health, Drexel University and Upenn: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff (   China CDC: Yiming Shao, M.D, Ph.D Guodong Mi, Ph.D, MPH Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China (  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! 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O  y,h8!Research Progress on HIV Vaacines""(!    sUntil now, all the HIV vaccines trials are proven to be unsucsessful due to hyper mutation and immune escape of HIVt    HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. Z  gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM  $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PP^%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new HIV infections in men, 72% were in MSM, and of new infections in MSM, 46% were in whites, 35% were in blacks and 19% were in Hispanics.   , In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu. The mean infection rate among MSM is 5%(2% in US) 2010, MSM represented 10.8% of newly reported cases. In 2008, a large-scale cross-sectional survey of more than 18 000 MSM in 61 major cities of China found an HIV prevalence of 5.0% and a prevalence greater than 10% in several southwest cities jnZZnZZ    -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  MThe first confirmed MSM case, a man in Beijing, in mainland China was in 1989. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community Nr3M  : These results highlight that student MSM, despite their high level of education and the previous perception that they are a low-risk group by researchers, have actually become a high-risk population for HIV infection in China.   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. FPqp 1#Health Intervention to MSM in China($#((#  In view of tradition and current status, at least four factors play roles in spread and control of HIV among MSM in China. (1) a mainstream belief on relation between fertility and sex that is inherited from belief as early as the twentieth century; (2) Ideologized and stereotyped same-gender sex and its residual effects, beginning politically and culturally from 1900-1970; (3) Effects on understanding of same-gender sex of China s Opening and Reform Policies beginning from 1980 and the globalization trend in the world; (4) Development of China s society and their response to AIDS. NPNM  5 There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. Z  6Prevention of HIV among MSM  Pexpand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies, condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 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O  <@h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu. The mean infection rate among MSM is 5%(2% in US) 2010, MSM represented 10.8% of newly reported cases. In 2008, a large-scale cross-sectional survey of more than 18 000 MSM in 61 major cities of China found an HIV prevalence of 5.0% and a prevalence greater than 10% in several southwest cities jnZZnZZ    -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  ]The first confirmed MSM case, a man in Beijing, in mainland China was in 1989. Some sociologists found that 7.0% male college students had homosexual       !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~inclination (scholars in China often put bisexuals into homosexuals) MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community older gay men, 4^Zr33]  : These results highlight that student MSM, despite their high level of education and the previous perception that they are a low-risk group by researchers, have actually become a high-risk population for HIV infection in China. Restricted by political, cultural and custom elements [3], China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well Z  ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. FPqp 1#Health Intervention to MSM in China($#((#  In view of tradition and current status, at least four factors play roles in spread and control of HIV among MSM in China. (1) a mainstream belief on relation between fertility and sex that is inherited from belief as early as the twentieth century; (2) Ideologized and stereotyped same-gender sex and its residual effects, beginning politically and culturally from 1900-1970; (3) Effects on understanding of same-gender sex of China s Opening and Reform Policies beginning from 1980 and the globalization trend in the world; (4) Development of China s society and their response to AIDS. NPNM  5 There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. Z  @ there are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing P  6prophylaxis of HIV among MSM$ ((*     expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies, condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. sentinel surveillance The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 *JP' I  ? Efforts havebeen made to reduce stigma towardMSM among health professionals, including a national consultation meetingjointly attended by public health officialsand by MSM community leaders to helphealth workers understand MSM communities,and how they can work forthem and with them. Stigma and discriminationtoward MSM within familiesand in the wider community remainsenormous and has become the majorbarrier for MSM access to AIDS programs. Astrategic plan and guidelines for conductinginterventions among MSM weredeveloped in 2006 with substantial inputfrom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 P  7  =Acknowledgement School of Publich Health, Drexel University and Upenn: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff (   China CDC: Yiming Shao, M.D, Ph.D Guodong Mi, Ph.D, MPH Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China (  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPK0  (   d  Px?Rectangle 39X lHIV/AIDS Research Progress and Prevention for Men Who Have Sex with Men (MSM) in China and the United States$m mg l      Nl?Rectangle 6z d-  s Yang Wang         Dܞ?ckeb_/web_ 1 e ;School of Biomedical Engineering, Sciences and Health Systems Department of Microbilogy and Immunology Vlog School of Medicine \? O 2=""M""   V  <d61 1?"6@ NNN?NHh >International Student Conference on Global Challenges: Gender .? 2=&&>  H  0޽h ? 3___PPT10i.H+D=' = @B +" 0     (  &  Jt?ckeb_/web_ 4m $Epidemiology of HIV in United States% % 6     D  Du?ckeb_/web_ 6Z<___PPT10Z___PPT9<4  In 2009, people living with HIV or AIDS in the world: 33.3 million. In US, by the end of 2010, 1,200,000 adults and children were estimated to be living with HIV. Among them, 17,774 died of HIV-related causes in 2009.  5"" &" c  g G c  g & c  "  " <                   G    &     <A 1?"6@ NNN?N{? 5iy  < 1?"6@ NNN?NY M` eUNAIDS Global AIDS Response Progress Reporting 2012 UNITED STATES OF AMERICA Country Progress Report *f 2eaae  | `> \4 S .0000S 2"vZ p  A??Zprevalence_mapPicture 3C:\Users\Lijun Gu\Desktop\prevalence_map.png`u>/  \A???Picture 4 /> \4  \A???Picture 5`>`uH  0޽h ? 3___PPT10i.B+D=' = @B +" 0 P2E(  X . C 0A 51dv4iDxreLh 7  j??Rectangle 127"@J q  &    r / S 9   r 1 S p K   - s *?'g% > H ! 0޽h ? 3___PPT10i.F0&M+D=' = @B +" 0 p<H(  f : C >A&891431251243105332n1 (  f#1??Text Box 573 HIV Treatment- HARRT, 2$&$   r < S  o W   H 5 0޽h ? 3___PPT10i. +D=' = @B +"0  0(    J<?ckeb_/web_ 2  w HIV Cure:         FD?ckeb_/web_ 12i  After 2012, HIV cure gradually became a hotspot in HIV reseach. It commonly includes novel drugs, gene therapy, and bone marrow transplantation (BMT) CM Durand, et al., Nature, 2013 b [@&& c&8         <A  1?"6@ NNN?NPE  <A 1?"6@ NNN?N J  <T  1?"6@ NNN?NY YS ^News, Nature, 2013 2" H   0޽h ? 3___PPT10i.E0V%p+D=' = @B +" 0 G v(     Tt?Rectangle 2"@ g L ^  e  r C S u `}   r D S Pvk [  R F C *A untitled H @ 0޽h ? 3___PPT10i.H+D=' = @B +" 0  $b(  $ $ XĊ1?Rectangle 259"@T HIV Epidemic among MSM in US $    $ <A 1?"6@ NNN?N~4 r $ S     r  $ S 4, Z  f  $ BW 1?"6@ NNN?N-Q M f Centers for Disease Control and Prevention. HIV prevalence estimates: United States, 2006. MMWR 2008;g(2gag H $ 0޽h ? 3___PPT10i.})+D=' = @B +" 0  X (  > S X$1?Rectangle 259"@8 $HIV Epidemic among MSM in US (cont.)2% &$g$$   r W S :z'   X <T 1?"6@ NNN?Nw% B AJoseph A. Catania et al. American Journal of Public Health, 2001 bA8nFP 2c(cgA  H  0޽h ? 3___PPT10i.n`iR+D=' = @B + 0 p(  r  S  'g<    S ~0e0e?#" 0e }   H  0޽h ? 380___PPT10.= 6$ 0 l$(  lr l S ) `}   r l S    H l 0޽h ? 380___PPT10.>X2y  0   (  r  S  `}   n   :0e0eA     @  1 8c8c     ?A)BCD|E||# "0e@       @ABC DEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN 5%  N 5%  N    5%    !"?N@ABC DEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab H  0޽h ? 3___PPT10i.=0N+D=' = @B +} 0  $(   r   S  `}   r   S  `  H   0޽h ? 3___PPT10i.=>+D=' = @B + 0 \(  \r \ S L `}    \ C x$0e0e?#" 0e `  H \ 0޽h ? 380___PPT10.j>dD$ 0 0t$(  tr t S p `}   r t S > `  H t 0޽h ? 380___PPT10.>ۺ 0 >6 ,(  ,r , S tW `}   r , S LX `   , <A  1?"6@ NNN?N H , 0޽h ? 380___PPT10.B>,$ 0  p$(  pr p S z `}    r p S { `   H p 0޽h ? 380___PPT10.>WSb0  (     eeL?(0000 0000 0000000 17[   -f   t-ee5%L?000 0000000 2 u  - fIn conclusion, we established a detection system for K103N and M184V resistance mutation in different HIV-1 subtypes infected patients with PCR-SSOP-Luminex assay. This novel method is rapid, simple, and high throughput. With the development of suitable primers and oligoprobes, this assay may be an appropriate technique for the surveillance of transmitted HIV drug resistance, clinical practice and public health research in low- and middle-income countries. h   f     +  n-ee? 0000juS0000000 3c F  |* A   H  0-f ? 3380___PPT10.PauFrh8pD_,Y$)37# 2]=+B- dGP60X:jS>08E[Vc@1!](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ00ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  a=h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University : Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff .ZZ    China CDC: Yiming Shao, M.D, Ph.D Guodong Mi, Ph.D, MPH Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China .ZZ   <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPK 0 ]U(    S L `  "p`Pp%  X1?Rectangle 259"@w|  !HIV Epidemic among MSM in China " "&$!   H  0޽h ? 380___PPT10.=#K} 0  $(   r   S p@   r   S  `  H   0޽h ? 3___PPT10i.=>+D='  = @B + 0 \(  \r \ S L}    \ C x$0e0e?#" 0e `  H \ 0޽h ? 380___PPT10.j>dD$ 0 X$(  Xr X S " }   r X S # `  H X 0޽h ? 380___PPT10.i>Pϑ$ 0 ($(  (r ( S Gt   r ( S H `  H ( 0޽h ? 380___PPT10.?> .$ 0 0t$(  tr t S p}   r t S > `  H t 0޽h ? 380___PPT10.>ۺ$ 0 @x$(  xr x S 34}   r x S a `  H x 0޽h ? 380___PPT10.>@ 0 >6 ,(  ,r , S tWT   r , S LX `   , <A  1?"6@ NNN?N H , 0޽h ? 380___PPT10.B>,$ 0  p$(  pr p S z `}    r p S { `   H p 0޽h ? 380___PPT10.>WSb$ 0 P|$(  |r | S  `}   r | S T$ `  H | 0޽h ? 380___PPT10.>?  0 V N 0 0 (  0r 0 S g `}   n 0  :0e0eA     @  1 8c8c     ?A)BCD|E||# "0e@       @ABC DEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN 5%  N 5%  N    5%    !"?N@ABC DEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab2   0 <A 1?"6@ NNN?N2 0 B 1?"6@ NNN?N`C B  0 BD1?"0@NNN?N  2  0  < 31?"6@ NNN?Ne   0 N0 1?"6@ NNN?NF P T*0nFPa H 0 0޽h ? 3___PPT10i.S>pv+D='  = @B + 0 d(  dr d S  `}   r d S \    r d S 4p `  H d 0޽h ? 380___PPT10.p> d0  (     eeL?(0000 0000 0000000 17[   -f   t-ee5%L?000 0000000 2 u  - fIn conclusion, we established a detection system for K103N and M184V resistance mutation in different HIV-1 subtypes infected patients with PCR-SSOP-Luminex assay. This novel method is rapid, simple, and high throughput. With the development of suitable primers and oligoprobes, this assay may be an appropriate technique for the surveillance of transmitted HIV drug resistance, clinical practice and public health research in low- and middle-income countries. h   f     +  n-ee? 0000juS0000000 3c F  |* A   H  0-f ? 3380___PPT10.PauFrXYd#a,.w50Ft: =?@H5dB1!](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ00ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  a=h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University : Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff .ZZ    China CDC: Yiming Shao, M.D, Ph.D Guodong Mi, Ph.D, MPH Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China .ZZ   <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPK 0 d(  dr d S  `}   r d S \    r d S 4p `  H d 0޽h ? 380___PPT10.p> drx=MTGPB1!](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ00ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  a=h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University : Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff .ZZ    China CDC: Yiming Shao, M.D, Ph.D Guodong Mi, Ph.D, MPH Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China .ZZ   <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrP_PB1!](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ00ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  a=h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly ar      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{}~e thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University : Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff .ZZ    China CDC: Yiming Shao, M.D, Ph.D Guodong Mi, Ph.D, MPH Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China .ZZ   <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr B1!](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ00ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  a=h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University : Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff .ZZ    China CDC: Yiming Shao, M.D, Ph.D Guodong Mi, Ph.D, MPH Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China .ZZ   <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr=  fhB1!](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ00ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  a=h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University : Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff .ZZ    China CDC: Yiming Shao, M.D, Ph.D Guodong Mi, Ph.D, MPH Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China .ZZ   <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrhvhB1!](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ00ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  a=h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University : Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff .ZZ    China CDC: Yiming Shao, M.D, Ph.D Guodong Mi, Ph.D, MPH Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China .ZZ   <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr # B1](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ0|0ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  =h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China Hui Du, Coordinate Director <!PP3 !  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPK 0 d(  dr d S  `}   r d S \    r d S 4p `  H d 0޽h ? 380___PPT10.p> d9 0 PH`(  `r ` S \ `}    ` C AJJmh370_china_prayers_11032014-936x620International school students light candles to pray for passengers aboard Malaysia Airlines flight MH370, in Zhuji, Zhejiang province, March 10, 2014.  Reuters pic R ` <L 1?"6@ NNN?N~ J 153 Chinese and 38 Malaysians disappeared!!! K 2Kc J  H ` 0޽h ? 3___PPT10i.m>`+D=' E= @B +rT# < 0# ˈ B1](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ0|0ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  =h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China Hui Du, Coordinate Director <!PP3 !  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:         !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{}~/# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr  B1](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ0|0ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  =h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China Hui Du, Coordinate Director <!PP3 !  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr  _D B1](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ0|0ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  =h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China Hui Du, Coordinate Director <!PP3 !  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrD oD # B1](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ0|0ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  =h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China Hui Du, Coordinate Director <!PP3 !  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrW 3 B1](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ0|0ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  =h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China Hui Du, Coordinate Director <!PP3 !  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr  ] B1](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ0|0ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  =h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China Hui Du, Coordinate Director <!PP3 !  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr] ] o B1](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙ      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~ׯ0|0ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  =h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China Hui Du, Coordinate Director <!PP3 !  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr  3 B1](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ0|0ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  =h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China Hui Du, Coordinate Director <!PP3 !  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrg C v B1](G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I 2$PGP\2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3>ʚ;2ʚ;<4ddddS0g4EdEdʙׯ0|0ppp@ <4!d!dvS0L}<4BdBdvS0L} )___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp^___PPT9@8 ?  O  =h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay. PuPPuPuP+PPXp313d%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > "6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM. 2K , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu(prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0%(2.0% in US). Lnnn  -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  i2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection. "iZZji  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. The above circumstance indicates that spread of HIV among MSM in China may directly trespass to female populationThis suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community PPzPPqqq3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing    A&HIV Epidemic among MSM in China(cont.)0'G$G$&    Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.      6Prophylaxis for HIV among MSME8      ,1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Hold HIV test among MSM and establish more sentinel surveillance sites to The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >)ZZZZ-,  ? Q3.As trategic plan and guidelines for conducting interventions among MSM weredeveloped in 2006 with substantial inputf rom MSM community leaders.These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM whohad used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 Q  B 4. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 5. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 6. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. The Chinese government has mplemented some targeted policies, including issuing the China s Medium- and Long-Term Program (1998 2010), HIV/AIDS Reduction and Prevention Plan of Action (2006 2010) and the HIV/AIDS Reduction and Prevention Plan of Action (2011 2015) marginal populations. 6P PP 7  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, MPH William Way LGBT Community Center in Philadelphia : Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay center, China Hui Du, Coordinate Director <!PP3 !  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr+w w B1iZ(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L} U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPK0  L(   d  P?Rectangle 39X lHIV/AIDS Research Progress and Prevention for Men Who Have Sex with Men (MSM) in China and the United States$m mg l      N?Rectangle 6z d-  s Yang Wang         D|?ckeb_/web_ 1 e ;School of Biomedical Engineering, Sciences and Health Systems Department of Microbilogy and Immunology Vlog School of Medicine \? O 2=""M""   H  0޽h ? 3___PPT10i.H+D=' = @B +" 0  X (  > S Xt.1?Rectangle 259"@8 $HIV Epidemic among MSM in US (cont.)2% &$g$$   r W S H.:z' .  X <. 1?"6@ NNN?Nw% B AJoseph A. Catania et al. American Journal of Public Health, 2001 bA8nFP 2c(cgA  H  0޽h ? 3___PPT10i.n`iR+D=' = @B +$ 0 l$(  lr l S HX. `}  . r l S  Y.  . H l 0޽h ? 380___PPT10.>X2 0 ]U(    S p. ` . "p`Pp%  X{.1?Rectangle 259"@w|  !HIV Epidemic among MSM in China " "&$!   H  0޽h ? 380___PPT10.=#K} 0  $(   r   S .p@  . r   S . ` . H   0޽h ? 3___PPT10i.=>+D=' = @B +$ 0 X$(  Xr X S . }  . r X S . ` . H X 0޽h ? 380___PPT10.i>Pϑ$ 0 0t$(  tr t S L.}  . r t S . ` . H t 0޽h ? 380___PPT10.>ۺ$ 0 @x$(  xr x S .4}  . r x S . ` . H x 0޽h ? 380___PPT10.>@$ 0  ,$(  ,r , S .T  . r , S d. ` . H , 0޽h ? 380___PPT10.B>,$ 0  p$(  pr p S . `}  . r p S X. ` . H p 0޽h ? 380___PPT10.>WSb$ 0 P|$(  |r | S . `}  . r | S . ` . H | 0޽h ? 380___PPT10.>?  0 V N 0 0 (  0r 0 S ( 0 `}  0 n 0  :0e0eA     @  1 8c8c     ?A)BCD|E||# "0e@       @ABC DEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN 5%  N 5%  N    5%    !"?N@ABC DEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab2  0 0 <A 1?"6@ NNN?N2 0 B 1?"6@ NNN?N`C B  0 BD1?"0@NNN?N  2  0 < 31?"6@ NNN?Ne   0 N0 1?"6@ NNN?NF P T*0nFPa H 0 0޽h ? 3___PPT10i.S>pv+D=' = @B + 0 H(  H H H\?Rectangle 2"@wP j Conclusion  x $    H H0?Rectangle 3pcD<4___PPT9  HIV has become a chronic infectious disease due to HARRT adoption. However, HIV vaccines are not developed sucssesfully. MSM community is still the high-risk population in transmitting HIV. HIV epidemic among MSM between US and China not only share a variety of similarities, but also differnces due to cultural difference and political system. 3. in terms of HIV prevention among MSM community, corresponding measures should be adopted for prophylaxisB\! n  ""xy  D     k  H T+05 1?"6@ NNN?N  +   H T05 1?"6@ NNN?N  +   H T:07 1?"6@ NNN?N m  +  H H 0޽h ? 3___PPT10i.K\!+D=' = @B +" 0 d(  dr d S =0 `}  0 r d S 0>0   0 r d S >0p ` 0 H d 0޽h ? 380___PPT10.p> dr` `/ \ $5 ,G< ., :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L} U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrCh h B1iZ(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L}      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~ U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr  YB1iZ(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L} U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKriwB1iZ(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L} U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr2xxB1iZ(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}ׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L} U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrH-B1iZ(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L} U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr|-X-B1iZ(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L} U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|~      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr!B1iZ(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L} U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr7=B1iZ(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L} U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrk=G=ܗB1iZ(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L} U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrB1iZ(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L} U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKr&MB1iZ(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L} U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrZM6M˧B1iZ(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L} U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neig      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHhborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! K& _rels/.rels ( 0nS=H^DtiUۛc a)hěBUrdk)Dd gIDr*dS("QlT3Q4b̜'օ9I]e3\0ťQ.D=vtr5aƓI+D#V0;f[e!/PK!2Vp7 tableStyles.xmlVn@# QI8}cU׻jR!.w$>qC>\ cv"JVf潙}3U9b&FTxgb(VDKA]|Ac|8xOzjʟ N ("ϕZL34$\P d?Gdܴ[}3$L`ů:#8Αqpro8m6-kt;ѣ5jƃ<9wxFBˏ/}&_{O/? (Mޥɧ4^~N/˹t2MVzHNirqȄ~j#tNxg>s*? UP^e ~ZkZp %gq`fq#67SWr\2ETJT񙈙O7Uȏ/Z<*2j 7nyԼJMBB>[pG5l\73ta*;ٷȫ{)+DBy}runVcB VjשިZu=լr ]^bH}Nw%~=[ (+T~^$:~ㅮA/|U/PK-!V[Content_Types].xmlPK-! K& 0_rels/.relsPK-!2Vp7 tableStyles.xmlPKrۧpB1iZ(G / 0DTimes New RomanLL}Ԗׯ0ԖD-3 00000 RomanLL}Ԗׯ0Ԗ" DArial00 RomanLL}Ԗׯ0Ԗ"0DGaramond RomanLL}Ԗׯ0Ԗ@DWingdingsRomanLL}Ԗׯ0ԖPD-3 0fggsRomanLL}Ԗׯ0Ԗ`DHGPfgBgsRomanLL}Ԗׯ0Ԗe(.2 @n?" dd@   @@`` f^|`' 3=H KE8';*, -     /Y84789 :ABC JKMNOPQRSTUR$1lDq Q#2$М+0و?_z#b$wGJ[e9 b$z~{;O=jI b$GMi$TAztn R$,4MNDW]J43) b$:C)<27"01%%i9b$093f28>, :8I $2$}XhZ@_sR$?G&-97b$= D'EKXl0$b$/]^KڧXo ?YLR$Ixu.-'_j37yXb$j7$E<ƛT Wb$j$߃ y̨'[uч 0e0e     A@  A1 8c8c     ?1 d0u0@Ty2 NP'p<'pA)BCD|E||s " 0e@        @ABC DEEFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `abN E5%  N E5%  N F   5%    !"?N@ABC DEFFGHIJK5%LMNOPQRSTUWYZ[ \]^_ `ab 3f@3nʚ;2ʚ;<4ddddS0g4EdEdD͙ׯ0Tppp@ <4!d!dvS0L}<4BdBdvS0L} U)___PPT12 %___PPT10D-3 00000 RomanLL̕ׯ0̕"DTimes New RomanLL̕ׯ0̕ D-3 0fgew RomanLL̕ׯ0̕ pp?  O  ;h8 Research Progress on HIV Vaccine!!(     0Until now, all the HIV vaccine trials are proven to be unsucsessful due to hyper-mutation and immune evasion of HIV failure of new HIV vaccine trial (HVTN505):a vaccine regimen consisting of a DNA vector encoding HIV-1 Gag, Pol, Nef and Env proteins followed by a recombinant adenovirus type 5 (rAd5) 0tZZZ11     HAART is the name given to aggressive treatment regimens used to suppress HIV viral replication and the progression of HIV disease. The usual HAART regimen combines three or more different drugs such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI) or other such combinations. 0ZZZ   gBerlin Patient    Timothy Brown, also known as  TheBerlin Patient, is thought to be the only individual functionally cured of HIV. wwv      In 2008, the US Centers for Disease Control and Prevention (CDC) estimated that at the end of 2006, approximately 1.1 million persons (prevalence rate 447.8 per 100 000 or 0.45%) were living with HIV in the United States. Of these, nearly half (48.1%) were MSM.&3   $  1. HIV prevalence varies extensively, with the highest prevalence figures observed for low socioeconomic status men, African Americans, injection drug users, and heavy non-injection substance users 2. HIV prevalence was higher among MSM in their 40s, those who were fully out, and more strictly homosexual men or men who self-identified as gay.  PuPPuPuP+PPWp313a%  ($HIV Epidemic among MSM in US (cont.)*% $$$  3. New York City and Los Angeles contain the 2 largest MSM communities in the United States, Chicago contains a focal community for MSM in the northern Midwest, and San Francisco has the highest-density MSM neighborhoods of any US city. These 4 cities alone hold more than one third of all MSM AIDS cases in the United States. Furthermore, these cities also are common vacation destinations for many MSM and thus may provide geographic foci from which HIV infection may spread to other areas of the country. $ZZ  +$HIV Epidemic among MSM in US (cont.)0%G$G$$  4. Overall, the estimated HIV incidence among black MSM was 8.0 times higher than among white MSM. Of new infections in MSM, 46% were in whites, 35% were I n african americans and 19% were in Hispanics. 5. When many MSM saw close friends, partners and lovers die gay communities adopted a range of practices to reduce the risk of infection successfully by changing sexual behaviours. Regretfully, these achievements did not last; many other developed countries also recorded a resurgence in the number of MSM newly diagnosed with HIV/AIDS since the mid-1990s. The main reason for the re-emergence of thedisease was the come-back of risky sexual behaviours, triggered by wider social and cultural changes, greater social acceptance for gay men and, somehow unpredictably, the introduction of more efficient drugs B@PP dA  > $6. Another main factor for the resurgence of AIDS among the gay communities in US is, ironically, the efficiency of HAART AIDS Fatigue. 7. the rise of internet-dating sites has increased the ease with which new partners can be found to facilitate HIV infection among MSM.  , 1. In mainland China, several recent cross-sectional studies among MSM show HIV prevalence ranging from 0.5% in Jinan to 8.5% in Chongqing and 9.1% in Chengdu (prevalence greater than 10% in several southwest cities). The mean infection rate among MSM is 5.0% in China(2.0% in US). 4   -  .&HIV Epidemic among MSM in China(cont.)0'G$G$&  j2. Some sociologists found that 7.0% male college students had homosexual inclination (scholars in China often put bisexuals into homosexuals) . Suprisingly, college male students that commonly are thought to be low prevalence for HIV have become high-risk population for HIV infection 3. In recent years, older gay men account for more and more HIV infection.  jkj  :&HIV Epidemic among MSM in China(cont.)0'G$G$&   4. Owing to being Restricted by political, cultural and custom elements, China is lagging behind in study on relationship between MSM and HIV/AIDS, and lacking involved data and corresponding health interventions as well   ;&HIV Epidemic among MSM in China(cont.)0'G$G$&  5. Due to ingrained perception of marrige and childbearing, MSM in China present different chacteristic compared with MSM in US. As for China, 70-80% of welleducated gays or bisexuals in metropolitan areas has or will get married with women. The proportion in rural areas may climb to 90% and marriage with women usually becomes inevitable because the incoming severe societal pressure if they do not get married. This suggests that MSM could also potentially act as a bridge to transmit HIV to the general female population. MSM in developed nations scarcely had sex or get married with women and the spread is confined to MSM community nPP PP#q3 5&HIV Epidemic among MSM in China(cont.)0'G$G$&  6. There are 56 ethnicities in China, the majority of which is the Han ethnicity (91.5%), and Chinese ethnic minority MSM are considered to be a high-risk subpopulation of MSM. MSM in Kunming, Yunnan Province found that the incidence of HIV among minority MSM was 10.1/100 PYs, which was significantly higher than Han-ethnic MSM (2.3/100 PYs). Additionally, minority MSM are also at risk of spreading HIV to the general population. Ethnic minority MSM were more likely to have sex with women compared to MSM who are of Han ethnicity. HIV prevention and behavioral intervention programs should focus their efforts on targeting these subpopulations of student and minority MSM. $ZZ  @&HIV Epidemic among MSM in China(cont.)0'G$G$&  7. There are many new factors that can significantly increase the rate of HIV transmission among men who have sex with men (MSM), including low HIV testing rates, high HIV incidence, high prevalence of syphilis infection and migration. The newly emerging HIV epidemic among MSM has been fueled by several factors, including low HIV testing rates, high prevalence of syphilis, persistent stigma against homosexuality and traditional concepts toward marriage and childbearing >ZZZZ  A&HIV Epidemic among MSM in China(cont.)0'G$G$&   8. Low HIV testing rates and high rates of high-risk sexual behaviors are major factors that correlate with the HIV epidemic among MSM. The effect of traditional Chinese culture is another major factor that iscorrelated with the HIV epidemic among MSM in China.   6Prophylaxis for HIV among MSME8      T1. Efforts should be made to reduce stigma toward MSM. Stigma and discrimination toward MSM within families and in the wider community remains enormous and has become the major barrier for MSM access to AIDS programs. 2. Carry out HIV test among MSM periodically and establish more sentinel surveillance sites to track HIV progression The number of sentinel surveillance sites focused on this group has increased from 3 sites in 2005 to 9 sites in 2007 to 56 sites in 2009. The percentage of MSM tested for HIV who knew their result increased from 32.7% in 2007 to 44.9% in 2009 in China >QPPPPUT  ?Prophylaxis for HIV among MSMG(8      U As trategic plan and guidelines for conducting interventions among MSM were developed in 2006 with substantial input from MSM community leaders. These programs reached anaverage of 85,727 MSM per month in 2009 and the percentage of MSM who had used a condom during their last sexual encounter increased from 64.4% in2007 to 73.1% in 2009 UVU  BProphylaxis for HIV among MSMG(8      3. NGO for MSM should be given more freedom and less control by government to better facilitate HIV prevention among MSM. 4. condom promotion among HIV positive MSM is another effective strategy to prevent HIV transmission, especially because it is very inexpensive compared with administering early ART. 5. expand media, education, and HIV testing programs among MSM Compared with early HIV treatment strategies. 6ZZZ 7#Looking at What does Scientists Say$$($  =Acknowledgement School of Publich Health, Drexel University: Randel Sell, Ph.D,C MPH William Way LGBT Community Center in Philadelphia : Chris Bartlett, Director Avis, Staff 2PP   BChina CDC: Yiming Shao, M.D, Ph.D Guodong Mi, M.D, Ph.D Sex Health Center of the Affiliated Hospital of Medical College Qingdao University, China: Beichuan Zhang, M.D  Tongai Gay Center, China Xiaohan Xiang, Director  Tongzhiyifanren Gay Center, China Hui Du, Coordinate Director <!PP3!  <:Pray for passengers aboard Malaysia Airlines flight MH370 ";9((:   /# 9( PK!V[Content_Types].xml (|N0H+8 (8ĪVEBpֻ3iVwbl VLly Ё9!u{yL IuF^k2#z cẽN`0[mb` \!#s,Hё9}~TU 6Ul¼;{-dۡx/ ftΓCR}o v|i@T;\/E_PK! 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" # $ % & ' m F G H I J K L M N O P Q R S T U V W X Y Z [ \ ] ^ _ ` a b c d e f g h  k Pn o p q r s t u v w x y z { | }   rophylaxis for HIV among MSMProphylaxis for HIV among MSMProphylaxis for HIV among MSM$Looking at What does Scient$_%] Windows UserWindows Usists Say õƬ 25Acknowledgement;Pray for passengers aboard Malaysia Airlines flight MH370  õʾĸģ õƬer